MSLN
GeneName
MSLN
Summary
MSLN, also known as mesothelin or MPF, is a 69 kDa glycoprotein that is primarily expressed on the surface of mesothelial cells and in certain types of cancer cells, particularly mesothelioma and ovarian cancer. It is localised to the plasma membrane and the extracellular region, and plays a role in cell adhesion and cell-matrix adhesion processes. MSLN is involved in mediating interactions between cells and the extracellular matrix, which is crucial for maintaining tissue architecture and facilitating cellular communication. Additionally, MSLN is secreted into the extracellular space, where it may have roles in tumour progression and immune evasion.
Importance
MSLN is relevant to: - Cancer biology, particularly in mesothelioma and ovarian cancer, where it serves as a potential biomarker for diagnosis and prognosis - Therapeutic targeting in oncology, as MSLN is a candidate for antibody-drug conjugates and other targeted therapies - Understanding cell adhesion mechanisms, which are vital in cancer metastasis and tissue integrity - Investigating the role of mesothelial cells in various physiological and pathological processes.
Top Products
For researchers investigating MSLN, we highly recommend the top-selling recombinant antibody, Anti-Mesothelin antibody [EPR4509] (ab133489). This antibody has been validated for use in immunohistochemistry (IHC), western blotting (WB), and immunoprecipitation (IP), making it a versatile tool for various experimental needs. With 8 citations, it has garnered attention in the research community, reflecting its reliability and effectiveness in detecting mesothelin. This product is an excellent choice for those seeking consistent performance in their studies. The Anti-Mesothelin antibody ELISA Kit (ab168740) is a reliable option for researchers looking to measure MSLN levels in their samples.
Abcam Product Citation Summary
The data indicates that MSLN is being studied in the context of human pancreatic ductal adenocarcinoma, highlighting its potential relevance in cancer research and diagnostics.
Abcam Product Citation Table
Function
Membrane-anchored forms may play a role in cellular adhesion.
Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
Involvement in disease
Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.
Post-translational modifications
Both MPF and the cleaved form of mesothelin are N-glycosylated.
Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.
Sequence Similarities
Belongs to the mesothelin family.
Tissue Specificity
Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).
Cellular localization
- Cell membrane
- Lipid-anchor
- GPI-anchor
- Golgi apparatus
- Megakaryocyte-potentiating factor
- Secreted
- Isoform 3
- Secreted
Alternative names
MPF, MSLN, Mesothelin, CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor