Prostate Secretory Protein/PSP

Prostate cancer, hereditary, 13

HPC13

A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.

None

Disease susceptibility is associated with variants affecting the gene represented in this entry.

Belongs to the beta-microseminoprotein family.

Strongly expressed in prostate, liver, kidney, breast and penis. Also expressed in pancreas, esophagus, stomach, deodenum, colon, trachea, lung, salivary glands and fallopian tube. PSP94 is expressed in lung and breast, whereas PSP57 is found in kidney and bladder.

• Secreted
• Sperm surface.

PRSP, MSMB, Beta-microseminoprotein, Immunoglobulin-binding factor, PN44, Prostate secreted seminal plasma protein, Prostate secretory protein of 94 amino acids, Seminal plasma beta-inhibin, IGBF, PSP-94, PSP94

• entrezGene:4477
• omim:157145
• swissprot:P08118

Proteins

Oncology

12865Da