MSR1
GeneName
MSR1
Summary
MSR1, also known as SR A or SRA, is a 50kDa scavenger receptor that is primarily expressed in macrophages and plays a vital role in the immune response. It is localised to the plasma membrane and endocytic vesicles, where it functions in the recognition and clearance of various ligands, including amyloid-beta and low-density lipoprotein particles. MSR1 is involved in several biological processes, such as amyloid-beta clearance, cholesterol transport, and the regulation of macrophage foam cell differentiation, thereby contributing to lipid homeostasis and immune regulation.
Importance
MSR1 is relevant to: - Alzheimer’s disease through its role in amyloid-beta clearance, potentially influencing disease progression - Atherosclerosis due to its involvement in cholesterol transport and foam cell formation - Immune response regulation as it mediates phagocytosis and receptor-mediated endocytosis of pathogens - Metabolic disorders linked to dysregulated lipid metabolism and macrophage function
Top Products
For researchers investigating MSR1, we recommend two primary antibodies that have garnered attention in the field. The first is the well-cited polyclonal antibody, Anti-CD204 antibody (ab123946), which has been referenced in 20 publications and is known for its effectiveness in Western blotting (WB) and immunocytochemistry (ICC). This antibody has established itself as a reliable choice for MSR1 studies. Additionally, we offer the recombinant antibody, Anti-CD204 antibody [EPR7536] (ab151707), which is also suitable for WB and has 19 citations to its name. The recombinant nature of this antibody ensures batch-to-batch consistency, making it an excellent option for researchers seeking dependable results in their experiments.
Abcam Product Citation Summary
The data indicates that the MSR1 antibody (ab123946) has been consistently used in studies focusing on macrophage signalling pathways in mouse models. This suggests a significant interest in understanding the role of MSR1 in macrophage biology.
Abcam Product Citation Table
Function
Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL) (PubMed:2251254). Isoform III does not internalize acetylated LDL (PubMed:9548586).
Involvement in disease
Prostate cancer
PC
A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
None
The disease may be caused by variants affecting the gene represented in this entry. MSR1 variants may play a role in susceptibility to prostate cancer. MSR1 variants have been found in individuals with prostate cancer and co-segregate with the disease in some families.
Barrett esophagus
BE
A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes.
None
The disease may be caused by variants affecting the gene represented in this entry. Genetic variants in MSR1 have been found in individuals with Barrett esophagus and are thought to contribute to disease susceptibility.
Tissue Specificity
Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages. Isoform I and isoform II are expressed in the liver, placenta and brain.
Cellular localization
- Membrane
- Single-pass type II membrane protein
Alternative names
CD204, SCARA1, MSR1, Macrophage scavenger receptor types I and II, Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1
Database links
swissprot:P21757 entrezGene:4481 omim:153622
Other research areas
- Immuno-oncology