MSTN

Acts specifically as a negative regulator of skeletal muscle growth.

Muscle hypertrophy

MSLHP

A condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong.

None

The disease is caused by variants affecting the gene represented in this entry.

Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.

Belongs to the TGF-beta family.

• Secreted

GDF8, MSTN, Growth/differentiation factor 8, GDF-8, Myostatin

• entrezGene:2660
• omim:601788
• swissprot:O14793

Proteins

Neuroscience

42750Da