MT1A

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Belongs to the metallothionein superfamily. Type 1 family.

MT1S, MT1A, Metallothionein-1A, MT-1A, Metallothionein-IA, MT-IA

• entrezGene:4502
• entrezGene:4489
• omim:156360
• omim:156350
• swissprot:P04731
• swissprot:P02795

Proteins

Oncology

6120Da