MT1A

GeneName

MT1A

Summary

MT1A, also known as MT2 or MT-1, is a low molecular weight protein (6 kDa) that is primarily expressed in the cytoplasm and nucleus of cells. It plays a vital role in metal ion binding, particularly with zinc ions, and is involved in the detoxification of heavy metals such as cadmium and copper. MT1A contributes to intracellular zinc ion homeostasis and is implicated in the regulation of cellular responses to metal exposure, as well as in the negative regulation of growth. This protein is part of the metallothionein family, which is known for its ability to bind metal ions and protect cells from metal toxicity.

Importance

MT1A is relevant to: - Heavy metal detoxification processes, particularly in response to cadmium and copper exposure - Maintenance of zinc homeostasis, which is essential for various cellular functions - Understanding mechanisms of metal-induced toxicity and cellular stress responses - Potential implications in conditions related to metal dysregulation, such as neurodegenerative diseases and cancer

Top Products

For researchers investigating MT1A, we recommend the well-cited Anti-Metallothionein antibody [UC1MT] (ab12228). This monoclonal antibody is highly regarded for its performance in Western blotting (WB), immunocytochemistry (ICC), and flow cytometry (FC). With 59 citations, it demonstrates a strong presence in the research community, reflecting its reliability and effectiveness in various applications. This antibody is an excellent choice for those looking to study MT1A with confidence.

Abcam Product Citation Summary

The data indicates that the MT1A target is being investigated in the context of oxidative cell damage, specifically in human ftRPE cells. The use of Western blotting and immunocytochemistry-immunofluorescence (ICC-IF) suggests a focus on protein expression and localisation in this biological context.

Abcam Product Citation Table

Domain

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Sequence Similarities

Belongs to the metallothionein superfamily. Type 1 family.

Alternative names

MT1S, MT1A, Metallothionein-1A, MT-1A, Metallothionein-IA, MT-IA

Database links

swissprot:P04731 entrezGene:4502 entrezGene:4489 swissprot:P02795 omim:156360 omim:156350