MTARC2

Function

Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:21029045, PubMed:24423752). As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed:21029045, PubMed:24423752). May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045). Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction (PubMed:21029045).

Post-translational modifications

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.

Cellular localization

• Mitochondrion outer membrane
• Peripheral membrane protein
• Peroxisome

Alternative names

• Mitochondrial amidoxime reducing component 2
• mARC2
• Molybdenum cofactor sulfurase C-terminal domain-containing protein 2
• MOSC domain-containing protein 2
• Moco sulfurase C-terminal domain-containing protein 2
• MTARC2
• MOSC2
• MARC2

Database links

• entrezGene:54996
• omim:614127
• swissprot:Q969Z3

Target type

Proteins

Molecular weight

38023Da