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MTARC2

Function

Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:21029045, PubMed:24423752). As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed:21029045, PubMed:24423752). May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045). Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction (PubMed:21029045).

Post-translational modifications

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.

Cellular localization

  • Mitochondrion outer membrane
  • Peripheral membrane protein
  • Peroxisome

Alternative names

  • Mitochondrial amidoxime reducing component 2
  • mARC2
  • Molybdenum cofactor sulfurase C-terminal domain-containing protein 2
  • MOSC domain-containing protein 2
  • Moco sulfurase C-terminal domain-containing protein 2
  • MTARC2
  • MOSC2
  • MARC2

Target type

Proteins

Molecular weight

38023Da