MTCL1
Function
Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225).
Post-translational modifications
Phosphorylated during mitosis in a CDK1-dependent manner.
Sequence Similarities
Belongs to the SOGA family.
Cellular localization
- Lateral cell membrane
- Apical cell membrane
- Cytoplasm
- Cytoskeleton
- Spindle pole
- Midbody
- Cytoplasm
- Cytoskeleton
- Colocalized with microtubules at the base of cilia. Gradually accumulates on the apicobasal microtubule bundles during epithelial cell polarization (By similarity). Colocalized with the apicobasal microtubule bundles running beneath the lateral membrane. Colocalized with microtubule bundles in the spindle pole in mitotic cells and in the midbodies at the end of cytokinesis.
Alternative names
CCDC165, KIAA0802, SOGA2, MTCL1, Microtubule cross-linking factor 1, Coiled-coil domain-containing protein 165, PAR-1-interacting protein, SOGA family member 2