MTERF3
Domain
Contains seven structural repeats of about 35 residues, where each repeat contains three helices. The repeats form a superhelical structure with a solenoid shape.
Function
Binds promoter DNA and regulates initiation of transcription (PubMed:17662942). Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity). Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (By similarity).
Sequence Similarities
Belongs to the mTERF family.
Tissue Specificity
Highly expressed in heart, liver, kidney and testis. Detected at lower levels in brain, spleen and lung.
Cellular localization
- Mitochondrion
Alternative names
MTERFD1, CGI-12, MTERF3, Mitochondrial transcription termination factor 3, mTERF3