MTERF4
Domain
The MTERF repeats form a half-donut shaped, right-handed superhelix, where the concave side displays a positively charged path for nucleic acid interaction.
Function
Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S).
Post-translational modifications
The mature mitochondrial protein exists in 2 forms differing at the level of their N-terminus, one is starting at residue 43 and the other at residue 48.
Sequence Similarities
Belongs to the mTERF family.
Cellular localization
- Mitochondrion
Alternative names
MTERFD2, HSPC096, MTERF4, Mitochondrial transcription termination factor 4, mTERF domain-containing protein 2