MTF1
Function
Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals (PubMed:8065932). Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (PubMed:8065932). Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (By similarity).
Cellular localization
- Nucleus
- Cytoplasm
- Translocation to the nucleus is induced by metals.
Alternative names
Metal regulatory transcription factor 1, MRE-binding transcription factor, Transcription factor MTF-1, MTF1