MTMR1
Domain
The C-terminal region is required for dimerization.
Function
Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate, generating phosphatidylinositol (PubMed:11733541, PubMed:27018598). Could also dephosphorylate phosphatidylinositol 3,5-bisphosphate to produce phosphatidylinositol 5-phosphate (PubMed:27018598).
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Cellular localization
- Cell membrane
- Peripheral membrane protein
- Cytoplasmic side
- Cytoplasm
Alternative names
Phosphatidylinositol-3-phosphate phosphatase MTMR1, Myotubularin-related protein 1, MTMR1