Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Regulates the level of these phosphoinositides critical for various biological processes including autophagy initiation and autophagosome maturation.
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
si:dkey-110k5.3, mtmr2, Myotubularin-related protein 2, Phosphatidylinositol-3-phosphate phosphatase
Proteins
Neuroscience
71109Da
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