mtmr2
Function
Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Regulates the level of these phosphoinositides critical for various biological processes including autophagy initiation and autophagosome maturation.
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Cellular localization
- Cytoplasm
- Early endosome membrane
- Peripheral membrane protein
- Partly associated with membranes.
Alternative names
si:dkey-110k5.3, mtmr2, Myotubularin-related protein 2, Phosphatidylinositol-3-phosphate phosphatase