MTMR3
Domain
The coiled coil domain mediates the interaction between MTMR3 and MTMR4. It is essential to bring together CEP55 and PLK1 during mitotic abscission.
Function
Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:10733931, PubMed:11302699, PubMed:11676921, PubMed:12646134). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic (PubMed:11302699, PubMed:11676921, PubMed:12646134). Could also have a molecular sequestering/adapter activity and regulate biological processes independently of its phosphatase activity. It includes the regulation of midbody abscission during mitotic cytokinesis (PubMed:25659891).
Post-translational modifications
Phosphorylated by CDK1 during mitosis.
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Cellular localization
- Cytoplasm
- Cytosol
- Membrane
- Peripheral membrane protein
Alternative names
KIAA0371, ZFYVE10, MTMR3, FYVE domain-containing dual specificity protein phosphatase 1, Myotubularin-related protein 3, Phosphatidylinositol-3-phosphate phosphatase, Zinc finger FYVE domain-containing protein 10, FYVE-DSP1