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MTNR1B

Function

High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Tissue specificity

Expressed in retina and less in brain and hippocampus.

Cellular localization

  • Cell membrane
  • Multi-pass membrane protein

Alternative names

  • Melatonin receptor type 1B
  • Mel-1B-R
  • Mel1b receptor
  • MTNR1B

Target type

Proteins

Molecular weight

40188Da