MTNR1B
Function
High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
Expressed in retina and less in brain and hippocampus.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
Melatonin receptor type 1B, Mel-1B-R, Mel1b receptor, MTNR1B