MT_POVMA
Domain
The NPTY motif is required for interaction with host Shc1 protein.
Function
Plays a role in transformation by modulating the activities of cellular proteins involved in control of cell proliferation and by acting as a functional homolog of an activated tyrosine kinase-associated growth-factor receptor. Recruits upon association with host Ppp2/PP2A the Src tyrosine kinase components Src, Yes and Fyn, thereby activating their kinase activity. Activation of Shc1, Pclg1 and p85 mediate signal transduction pathways leading to cell cycle progression and cell division. MT also plays a role in regulation of early and late gene expression and in viral DNA replication.
Post-translational modifications
Tyrosine-phosphorylated on three residues 250, 315 and 322, providing docking sites for host Shc1, p85, and Plcg1, respectively.
Cellular localization
- Host membrane
- Single-pass membrane protein
Alternative names
Middle T antigen, MT, MT-AG