Expression in the yolk sac tissues followed by expression in the primordial liver cell nests as early as day 9 post-coitum (9.5 dpc). Intestinal expression is detected around 12.5 dpc and attains full adult expression patterns by 14.5 dpc.
Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:15897609, PubMed:16478722, PubMed:18502767, PubMed:33168624). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:10713055, PubMed:17635917, PubMed:18502767, PubMed:33168624, PubMed:9502759). May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (PubMed:18502767).
Isoform 2
Critical for the development of natural killer T (NKT) cells (PubMed:17312007). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:17635917).
Isoform 2
Cleaved by signal peptidase between residues Gln-33 and Asn-34.
Isoform 1
Mainly expressed in the intestine and the liver, and at lower levels in white and brown fat cells (PubMed:17635917, PubMed:8660984). Expressed in heart (PubMed:9502759).
Isoform 2
Ubiquitous, and is the major isoform in hematopoietic cells and adipocytes.
Mtp, Mttp, Microsomal triglyceride transfer protein large subunit
Proteins
Metabolism
99099Da
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