MUC17
Function
Probably plays a role in maintaining homeostasis on mucosal surfaces.
Post-translational modifications
Probably cleaved within the SEA domain.
N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated.
Tissue Specificity
Expressed almost exclusively in the intestine. Expression is especially high in both the duodenum and transverse colon. Expressed in mature absorptive cells of the small intestinal villi. No expression is detected in goblet cells. Highly expressed in pancreatic adenocarcinoma tissue (at protein level). Expression is not detectable in normal pancreas, in pancreatitis or in cell lines derived from other cancers.
Cellular localization
- Isoform 1
- Cell membrane
- Single-pass membrane protein
- Isoform 2
- Secreted
- Cell membrane
Alternative names
MUC3, MUC17, Mucin-17, MUC-17, Small intestinal mucin-3, MUC-3