MUC3A

Function

Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling.

Post-translational modifications

Highly O-glycosylated and probably also N-glycosylated.

Tissue Specificity

Broad specificity; small intestine, colon, colonic tumors, heart, liver, thymus, prostate, pancreas and gall bladder.

Cellular localization

• Isoform 1
• Membrane
• Single-pass membrane protein
• Isoform 2
• Secreted
• Isoform 3
• Secreted
• Isoform 4
• Secreted
• Isoform 5
• Secreted

Alternative names

MUC3, MUC3A, Mucin-3A, MUC-3A, Intestinal mucin-3A

Database links

swissprot:Q02505 omim:158371 omim:605633 entrezGene:57876 entrezGene:4584 swissprot:Q9H195