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mutL

Function

This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of the final effector complex. The ATPase activity of MutL is stimulated by DNA.

Sequence Similarities

Belongs to the DNA mismatch repair MutL/HexB family.

Alternative names

b4170, JW4128, mutL, DNA mismatch repair protein MutL

swissprot:P23367