MVP
GeneName
MVP
Summary
MVP, also known as Lrp or P100, is a 99 kDa protein that is primarily localised in the cytoplasm and nucleus, and is associated with various cellular structures including the nuclear pore complex and ribonucleoprotein complexes. It plays a role in mRNA transport and is involved in the regulation of several signalling pathways, including the ERBB signalling pathway. MVP is known to bind to identical proteins as well as protein kinases and phosphatases, indicating its involvement in protein activation cascades and transport processes. Additionally, it participates in the negative regulation of epidermal growth factor receptor signalling and protein tyrosine kinase activity, highlighting its regulatory functions in cellular signalling and proliferation.
Importance
MVP is relevant to: - Understanding the mechanisms of mRNA transport and its implications in gene expression regulation - Investigating the role of MVP in signalling pathways, particularly those involving receptor tyrosine kinases, which are important in cancer biology - Exploring its involvement in cellular proliferation and the potential impact on tumour growth and development - Studying the interactions of MVP with various proteins, which can provide insights into cellular signalling networks and their dysregulation in diseases
Top Products
For researchers investigating MVP, we highly recommend the top-selling recombinant antibody, Anti-MVP antibody [EPR13227(B)] (ab175239). This antibody has been validated in knockout models, ensuring reliable performance in various applications, including Western blotting (WB), immunohistochemistry (IHC), immunocytochemistry (ICC), and flow cytometry (FC). With 7 citations, it is gaining recognition in the research community for its effectiveness and versatility in MVP detection. This product is an excellent choice for those seeking consistent and dependable results in their studies.
Abcam Product Citation Summary
The MVP antibody (ab175239) was utilised in a study focusing on the NF-κB signalling pathway, specifically in human A549 cells. This suggests a role for MVP in cellular signalling mechanisms related to inflammation or immune response.
Abcam Product Citation Table
Domain
MVP 3 mediates interaction with PTEN.
MVP 4 mediates interaction with PARP4.
Function
Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
Post-translational modifications
Phosphorylated on Tyr residues after EGF stimulation.
Dephosphorylated by PTPN11.
Tissue Specificity
Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.
Cellular localization
- Cytoplasm
- Nucleus
- Nuclear pore complex
- Cytoplasm
- Perinuclear region
- 5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665).
Alternative names
LRP, MVP, Major vault protein, Lung resistance-related protein