MX1

The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition.

The middle domain mediates self-assembly and oligomerization.

Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.

ISGylated.

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

• Cytoplasm
• Endoplasmic reticulum membrane
• Peripheral membrane protein
• Cytoplasmic side
• Cytoplasm
• Perinuclear region
• Binds preferentially to negatively charged phospholipids (PubMed:21900240). Colocalizes with CCHFV protein N in the perinuclear region (PubMed:15047845).
• Isoform 2
• Cytoplasm
• Nucleus
• Translocates into the nuclei of HSV-1 infected cells (PubMed:20603636).

Interferon-induced GTP-binding protein Mx1, Interferon-induced protein p78, Interferon-regulated resistance GTP-binding protein MxA, Myxoma resistance protein 1, Myxovirus resistance protein 1, IFI-78K, MX1

• entrezGene:4599
• omim:147150
• swissprot:P20591

Proteins

Immunology & Infectious Disease

75520Da