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MXD3

Function

Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).

Cellular localization

Alternative names

BHLHC13, MAD3, MXD3, Max dimerization protein 3, Max dimerizer 3, Class C basic helix-loop-helix protein 13, Max-associated protein 3, Max-interacting transcriptional repressor MAD3, Myx, bHLHc13

swissprot:Q9BW11 entrezGene:83463 omim:609450