MXRA5
Developmental stage
Over-expressed in centenarians. Expression is reduced from young to old but increased from old to centenarians.
Function
In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli.
Involvement in disease
Lung cancer
LNCR
A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.
None
Disease susceptibility may be associated with variants affecting the gene represented in this entry.
Tissue Specificity
Detected in placenta (at protein level) (PubMed:32337544). Detected in cerebrospinal fluid and fibroblasts (at protein level) (PubMed:25326458, PubMed:36213313). Highly expressed in kidney, also detected on liver and spleen (PubMed:27599751). Expressed by proximal tubular cells of the kidney (at protein level) (PubMed:27599751). Expression highly increases during chronic kidney disease and autosomal dominant polycystic kidney disease, where is detected in cysts (PubMed:27599751).
Cellular localization
- Secreted
Alternative names
Matrix-remodeling-associated protein 5, Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan, Adlican, MXRA5