MYB
Domain
Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression.
Function
Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
Post-translational modifications
Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
SUMOylated by TRAF7; leading to MYB transcriptional activity inhibition.
Phosphorylated by NLK on multiple sites, which induces proteasomal degradation.
Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels.
Cellular localization
- Nucleus
Alternative names
Transcriptional activator Myb, Proto-oncogene c-Myb, MYB