MYCT1
Function
May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity).
Sequence Similarities
Belongs to the MYCT1 family.
Tissue Specificity
Down-regulated in gastric cancer tissues.
Cellular localization
- Nucleus
- Expressed in nuclei of hepatocellular carcinoma cell line BEL-7402 cells.
Alternative names
MTLC, MTMC1, MYCT1, Myc target protein 1, Myc target in myeloid cells protein 1