MYDGF
Function
Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).
Sequence Similarities
Belongs to the MYDGF family.
Tissue Specificity
Expressed in eosinophils (at protein level) (PubMed:29954947). Expressed in bone marrow cells (PubMed:25581518). Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties (PubMed:17362502).
Cellular localization
- Secreted
- Endoplasmic reticulum-Golgi intermediate compartment
- Endoplasmic reticulum
- Golgi apparatus
- The C-terminal RTEL motif may provide retention in the endoplasmic reticulum.
Alternative names
C19orf10, MYDGF, Myeloid-derived growth factor