Myeloblastin

Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. May play a role in neutrophil transendothelial migration, probably when associated with CD177.

Belongs to the peptidase S1 family. Elastase subfamily.

• Lysosome
• Secreted
• Cell membrane
• Peripheral membrane protein
• Extracellular side
• Membrane raft
• Peripheral membrane protein
• Extracellular side
• Localizes predominantly to azurophil granules (primary secretory granules) in neutrophils. Secreted upon neutrophil stimulation by TNF-alpha, lipopolysaccharide (LPS), fMLP and CXCL8/IL8 or during neutrophil transmigration. Following secretion tethered to the cell membrane by CD177.

Myeloblastin, Proteinase 3, PR-3, Prtn3

• entrezGene:19152
• swissprot:Q61096

Proteins

Metabolism

27626Da