Myeloblastin
Function
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. May play a role in neutrophil transendothelial migration, probably when associated with CD177.
Sequence Similarities
Belongs to the peptidase S1 family. Elastase subfamily.
Cellular localization
- Lysosome
- Secreted
- Cell membrane
- Peripheral membrane protein
- Extracellular side
- Membrane raft
- Peripheral membrane protein
- Extracellular side
- Localizes predominantly to azurophil granules (primary secretory granules) in neutrophils. Secreted upon neutrophil stimulation by TNF-alpha, lipopolysaccharide (LPS), fMLP and CXCL8/IL8 or during neutrophil transmigration. Following secretion tethered to the cell membrane by CD177.
Alternative names
Myeloblastin, Proteinase 3, PR-3, Prtn3