MYG1
Function
3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk (PubMed:31081026). In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable).
Involvement in disease
Several works have found that mRNA expression is elevated in the skin of vitiligo patients.
Sequence Similarities
Belongs to the MYG1 family.
Tissue Specificity
Ubiquitously expressed, with highest levels in testis.
Cellular localization
- Nucleus
- Nucleoplasm
- Mitochondrion matrix
- Nucleus
- Nucleolus
Alternative names
C12orf10, MYG1, MYG1 exonuclease