MYH1

Domain

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.

Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).

Function

Muscle contraction.

Sequence Similarities

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

Cellular localization

• Cytoplasm
• Myofibril
• Thick filaments of the myofibrils.

Alternative names

Myosin-1, Myosin heavy chain 1, Myosin heavy chain 2x, Myosin heavy chain IIx/d, MyHC-2x, MyHC-IIx/d, MYH1

Database links

swissprot:P12882 entrezGene:4620 entrezGene:4619 entrezGene:4621 swissprot:Q9UKX2 swissprot:Q02045 swissprot:P60660 swissprot:P11055 swissprot:P13533 swissprot:P10916 swissprot:Q9Y623 swissprot:P12829 swissprot:P05976 entrezGene:4632 entrezGene:4633 entrezGene:4634 entrezGene:4635 swissprot:P08590 entrezGene:4636 entrezGene:4637 omim:160780 omim:160740 omim:160730 entrezGene:4624 entrezGene:4622