MYO1D
Domain
Binds a calmodulin chain via each of the two IQ domains. IQ domain 1 mediates interaction with calmodulin both in the presence and in the absence of Ca(2+). IQ domain 2 mediates interaction with calmodulin in the presence of Ca(2+).
The TH1 domain is required for activity in complementing zebrafish defects in Kupffer's vesicle lumen size.
Function
Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity). Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells (By similarity).
Sequence Similarities
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Tissue Specificity
Expressed in many tissues. Highest levels in brain, followed by lung and ovary; expression is lowest in spleen.
Cellular localization
- Cytoplasm
- Perikaryon
- Cell projection
- Dendrite
- Early endosome
- Cytoplasm
- Cell cortex
- Colocalizes with the actin cytoskeleton in the cell cortex close to the apical cell membrane. Colocalizes with cytoplasmic puncta that are reminiscent of transport vesicles.
Alternative names
KIAA0727, MYO1D, Unconventional myosin-Id