MYOZ1
Function
Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
Sequence Similarities
Belongs to the myozenin family.
Tissue Specificity
Expressed primarily in skeletal muscle. Detected at lower levels in heart, prostate and pancreas.
Cellular localization
- Nucleus
- Cell projection
- Pseudopodium
- Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle.
Alternative names
MYOZ, MYOZ1, Myozenin-1, Calsarcin-2, Protein FATZ