N
Function
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.
Post-translational modifications
ADP-ribosylated. The ADP-ribosylation is retained in the virion during infection.
Phosphorylated on serine and threonine residues.
Sequence Similarities
Belongs to the alphacoronavirus nucleocapsid protein family.
Cellular localization
- Virion
- Host endoplasmic reticulum-Golgi intermediate compartment
- Host Golgi apparatus
- Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.
Alternative names
6, N, Nucleoprotein, Nucleocapsid protein, NC, Protein N