NAB2
Domain
The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization.
The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression.
Function
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity).
Post-translational modifications
Sumoylation by EGR2 represses EGR2 transcriptional activity in hindbrain.
Sequence Similarities
Belongs to the NAB family.
Tissue Specificity
Widely expressed at low levels. Highly expressed in melanoma cell lines.
Cellular localization
- Nucleus
- Isoform 2 is not localized to the nucleus.
Alternative names
MADER, NAB2, NGFI-A-binding protein 2, EGR-1-binding protein 2, Melanoma-associated delayed early response protein, Protein MADER