NARS1

Domain

The N-terminal domain (1-77) recruits and activates specific immune cells by interacting with CCR3-expressing cells.

Function

Catalyzes the attachment of asparagine to tRNA(Asn) in a two-step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn) (PubMed:9421509). In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells (PubMed:30171954, PubMed:12235211).

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Cellular localization

• Cytoplasm

Alternative names

• Asparaginyl-tRNA synthetase
• Asparaginyl-tRNA synthetase 1
• AsnRS
• NARS1
• NARS
• NRS

Database links

• entrezGene:4677
• omim:108410
• swissprot:O43776

Target type

Proteins

Molecular weight

62943Da