NAT8
Function
Acetylates the free alpha-amino group of cysteine S-conjugates to form mercapturic acids (PubMed:20392701). This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241).
Pathway
Sulfur metabolism; glutathione metabolism.
Sequence Similarities
Belongs to the camello family.
Tissue Specificity
Preferentially expressed in liver and kidney. Also detected in brain (at protein level).
Cellular localization
- Endoplasmic reticulum-Golgi intermediate compartment membrane
- Single-pass type II membrane protein
- Endoplasmic reticulum membrane
- Single-pass type II membrane protein
Alternative names
CML1, GLA, TSC501, NAT8, N-acetyltransferase 8, Acetyltransferase 2, Camello-like protein 1, Cysteinyl-conjugate N-acetyltransferase, ATase2, CCNAT