NCAM1

GeneName

NCAM1

Summary

NCAM1, also known as NCAM, CD56, or NCAM-1, is a 95 kDa glycoprotein primarily expressed on the surface of neurons and in various other tissues. It is a member of the immunoglobulin superfamily and plays a vital role in cell adhesion and neuronal development. NCAM1 is localised to the plasma membrane and extracellular region, where it facilitates cell-cell interactions, particularly in the nervous system. Its involvement in processes such as commissural neuron axon guidance and epithelial to mesenchymal transition highlights its importance in both neural and developmental biology. Additionally, NCAM1 acts as a receptor for certain viruses, indicating its role in viral pathogenesis.

Importance

NCAM1 is relevant to: - Neural development and plasticity through its role in cell adhesion and axon guidance - Cancer research, particularly in the context of epithelial to mesenchymal transition, which is crucial for metastasis - Viral infections, as it serves as a receptor for specific viruses, impacting our understanding of viral entry mechanisms - Neurodegenerative diseases, where alterations in NCAM1 expression may influence neuronal survival and regeneration

Top Products

For researchers investigating NCAM1, we highly recommend the top-selling recombinant antibody, Anti-NCAM1 antibody [EP2567Y] (ab75813). This antibody has been validated for a variety of applications, including flow cytometry (FC), immunohistochemistry (IHC), western blotting (WB), immunocytochemistry (ICC), and immunoprecipitation (IP), making it a versatile tool for your research needs. With 66 citations, it has garnered significant attention in the scientific community, reflecting its reliability and effectiveness in NCAM1 detection. This product is an excellent choice for those seeking consistent performance in their experiments. The PE/Cy7® Anti-NCAM1 antibody [MY31] ELISA Kit (ab210305) is an excellent option for researchers looking to analyse NCAM1 in their experiments.

Abcam Product Citation Summary

The data indicates that NCAM1 is being studied in the context of ischemic neuropathy and Schwann cell regulation. The use of antibodies in both immunohistochemistry and Western blotting highlights the importance of NCAM1 in these biological processes.

Abcam Product Citation Table

Function

This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

(Microbial infection) Acts as a receptor for rabies virus.

(Microbial infection) Acts as a receptor for Zika virus.

Post-translational modifications

Polysialylated at Asn-459 and Asn-488 by ST8SIA2 and ST8SIA4 (PubMed:28810663). Polysialylation modulates cell interactions by confering both attractive and repulsive properties that are highly regulated by ST8SIA2 and ST8SIA4 (PubMed:28810663). Polysialylation is formed on a-2,3-linked sialic acid of core glycans (PubMed:9774483).

Cellular localization

• Isoform 1
• Cell membrane
• Single-pass type I membrane protein
• Isoform 2
• Cell membrane
• Single-pass type I membrane protein
• Isoform 3
• Cell membrane
• Lipid-anchor
• GPI-anchor
• Isoform 4
• Cell membrane
• Lipid-anchor
• GPI-anchor
• Isoform 5
• Secreted
• Isoform 6
• Secreted

Alternative names

CD56, NCAM, NCAM1, Neural cell adhesion molecule 1, N-CAM-1, NCAM-1

Database links

swissprot:P13591 omim:107266 omim:116930 swissprot:P20273 entrezGene:933 entrezGene:4684

Other research areas

• Immuno-oncology
• Neuroscience