NCAM1
Function
This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
(Microbial infection) Acts as a receptor for rabies virus.
(Microbial infection) Acts as a receptor for Zika virus.
Post-translational modifications
Polysialylated at Asn-459 and Asn-488 by ST8SIA2 and ST8SIA4 (PubMed:28810663). Polysialylation modulates cell interactions by confering both attractive and repulsive properties that are highly regulated by ST8SIA2 and ST8SIA4 (PubMed:28810663). Polysialylation is formed on a-2,3-linked sialic acid of core glycans (PubMed:9774483).
Cellular localization
- Isoform 1
- Cell membrane
- Single-pass type I membrane protein
- Isoform 2
- Cell membrane
- Single-pass type I membrane protein
- Isoform 3
- Cell membrane
- Lipid-anchor
- GPI-anchor
- Isoform 4
- Cell membrane
- Lipid-anchor
- GPI-anchor
- Isoform 5
- Secreted
- Isoform 6
- Secreted
Alternative names
CD56, NCAM, NCAM1, Neural cell adhesion molecule 1, N-CAM-1, NCAM-1