NCAPH2
Function
Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007).
Sequence Similarities
Belongs to the CND2 H2 (condensin-2 subunit 2) family.
Cellular localization
- Nucleus
- Chromosome
- Distributed along the arms of chromosomes assembled in vivo and in vitro.
Alternative names
CAPH2, NCAPH2, Condensin-2 complex subunit H2, Chromosome-associated protein H2, Kleisin-beta, Non-SMC condensin II complex subunit H2, hCAP-H2