Hydrolyzes 2-acetyl monoalkylglycerol ether (1-O-alkyl-2-acetyl-sn-glycerol), the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (PubMed:17052608). May be responsible for the hydrolysis of cholesterol esters (such as cholesteryl (9Z-octadecenoate)) in macrophages (By similarity). Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity). May contribute to cancer pathogenesis by promoting tumor cell migration (PubMed:17052608).
N-glycosylated.
Belongs to the 'GDXG' lipolytic enzyme family.
Expressed in monocyte-derived macrophages. Up-regulated in invasive melanoma and breast carcinoma cell lines.
AADACL1, KIAA1363, NCEH1, Neutral cholesterol ester hydrolase 1, NCEH, Acetylalkylglycerol acetylhydrolase, Arylacetamide deacetylase-like 1, 2-acetyl MAGE hydrolase
Proteins
Oncology
45808Da
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