NCEH1
Function
Hydrolyzes 2-acetyl monoalkylglycerol ether (1-O-alkyl-2-acetyl-sn-glycerol), the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (PubMed:17052608). May be responsible for the hydrolysis of cholesterol esters (such as cholesteryl (9Z-octadecenoate)) in macrophages (By similarity). Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity). May contribute to cancer pathogenesis by promoting tumor cell migration (PubMed:17052608).
Post-translational modifications
N-glycosylated.
Sequence Similarities
Belongs to the 'GDXG' lipolytic enzyme family.
Tissue Specificity
Expressed in monocyte-derived macrophages. Up-regulated in invasive melanoma and breast carcinoma cell lines.
Cellular localization
- Cell membrane
- Single-pass type II membrane protein
- Microsome
Alternative names
AADACL1, KIAA1363, NCEH1, Neutral cholesterol ester hydrolase 1, NCEH, Acetylalkylglycerol acetylhydrolase, Arylacetamide deacetylase-like 1, 2-acetyl MAGE hydrolase