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Function

Hydrolyzes 2-acetyl monoalkylglycerol ether (1-O-alkyl-2-acetyl-sn-glycerol), the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (PubMed:17052608). May be responsible for the hydrolysis of cholesterol esters (such as cholesteryl (9Z-octadecenoate)) in macrophages (By similarity). Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity). May contribute to cancer pathogenesis by promoting tumor cell migration (PubMed:17052608).

Post-translational modifications

N-glycosylated.

Sequence similarities

Belongs to the 'GDXG' lipolytic enzyme family.

Tissue specificity

Expressed in monocyte-derived macrophages. Up-regulated in invasive melanoma and breast carcinoma cell lines.

Cellular localization

  • Cell membrane
  • Single-pass type II membrane protein
  • Microsome

Alternative names

AADACL1, KIAA1363, NCEH1, Neutral cholesterol ester hydrolase 1, NCEH, Acetylalkylglycerol acetylhydrolase, Arylacetamide deacetylase-like 1, 2-acetyl MAGE hydrolase

Target type

Proteins

Primary research area

Oncology

Molecular weight

45808Da

We found 1 product in 1 category

Primary Antibodies

Target

Application

Reactive species

Search our catalogue for 'AADACL1' (1)

Products