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NOXA2/p67phox

OverviewProducts

Domain

The OPR/PB1 domain mediates the association with NCF4/p40-PHOX.

Function

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).

Involvement in disease

Granulomatous disease, chronic, cytochrome-b-positive 2, autosomal recessive

CGD2

A form of chronic granulomatous disease, a primary immunodeficiency characterized by severe recurrent bacterial and fungal infections, along with manifestations of chronic granulomatous inflammation. It results from an impaired ability of phagocytes to mount a burst of reactive oxygen species in response to pathogens.

None

The disease is caused by variants affecting the gene represented in this entry.

Sequence similarities

Belongs to the NCF2/NOXA1 family.

Cellular localization

  • Cytoplasm

Alternative names

  • Neutrophil cytosol factor 2
  • NCF-2
  • 67 kDa neutrophil oxidase factor
  • NADPH oxidase activator 2
  • Neutrophil NADPH oxidase factor 2
  • p67-phox

Database links

Target type

Proteins

Molecular weight

47515Da