NOXA2/p67phox

Domain

The OPR/PB1 domain mediates the association with NCF4/p40-PHOX.

Function

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).

Involvement in disease

Granulomatous disease, chronic, autosomal recessive, 2

CGD2

A form of chronic granulomatous disease, a primary immunodeficiency characterized by severe recurrent bacterial and fungal infections, along with manifestations of chronic granulomatous inflammation. It results from an impaired ability of phagocytes to mount a burst of reactive oxygen species in response to pathogens.

None

The disease is caused by variants affecting the gene represented in this entry.

Sequence similarities

Belongs to the NCF2/NOXA1 family.

Cellular localization

• Cytoplasm

Alternative names

• NOXA2
• P67PHOX
• P67PHOX
• NOXA2
• NCF2
• Neutrophil cytosol factor 2
• NCF-2
• 67 kDa neutrophil oxidase factor
• NADPH oxidase activator 2
• Neutrophil NADPH oxidase factor 2
• p67-phox

Database links

• entrezGene:4688
• omim:608515
• swissprot:P19878

Target type

Proteins

Primary research area

Neuroscience

Molecular weight

59762Da