NCF2
Domain
The OPR/PB1 domain mediates the association with NCF4/p40-PHOX.
Function
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
Involvement in disease
Granulomatous disease, chronic, autosomal recessive, 2
CGD2
A form of chronic granulomatous disease, a primary immunodeficiency characterized by severe recurrent bacterial and fungal infections, along with manifestations of chronic granulomatous inflammation. It results from an impaired ability of phagocytes to mount a burst of reactive oxygen species in response to pathogens.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the NCF2/NOXA1 family.
Cellular localization
- Cytoplasm
Alternative names
NOXA2, P67PHOX, NCF2, Neutrophil cytosol factor 2, NCF-2, 67 kDa neutrophil oxidase factor, NADPH oxidase activator 2, Neutrophil NADPH oxidase factor 2, p67-phox