NCK2
Function
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.
Post-translational modifications
Phosphorylated.
Tissue Specificity
Ubiquitous.
Cellular localization
- Cytoplasm
- Endoplasmic reticulum
Alternative names
GRB4, NCK2, Cytoplasmic protein NCK2, Growth factor receptor-bound protein 4, NCK adaptor protein 2, SH2/SH3 adaptor protein NCK-beta, Nck-2