NCL

Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.

Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).

Symmetrically methylated by PRMT5.

• Nucleus
• Nucleolus
• Cytoplasm
• Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Nucleolin, Protein C23, NCL

• entrezGene:4691
• omim:164035
• swissprot:P19338

Proteins

Epigenetics

76614Da