CIA

Contains one Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif that is essential for the association with nuclear receptors.

Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).

Widely expressed.

• Nucleus

KIAA1637, NCOA5, Nuclear receptor coactivator 5, NCoA-5, Coactivator independent of AF-2, CIA

• entrezGene:57727
• swissprot:Q9HCD5

Proteins

65536Da