Ncor1
Domain
The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3).
The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity.
Function
Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (By similarity). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (PubMed:24794873). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (PubMed:19037247).
Post-translational modifications
Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation.
Sequence Similarities
Belongs to the N-CoR nuclear receptor corepressors family.
Tissue Specificity
Ubiquitous.
Cellular localization
- Nucleus
Alternative names
Rxrip13, Ncor1, Nuclear receptor corepressor 1, N-CoR, N-CoR1, Retinoid X receptor-interacting protein 13, RIP13