NCOR2
Domain
The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2).
The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity.
The deacetylase activation domain (DAD) promotes the recruitment and activation of HDAC3 (PubMed:22230954). Inositol tetraphosphate (1D-myo-inositol 1,4,5,6-tetrakisphosphate) acts as an intermolecular glue between HDAC3 and NCOR2 (PubMed:22230954).
Function
Transcriptional corepressor that mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription (PubMed:10077563, PubMed:10097068, PubMed:18212045, PubMed:20812024, PubMed:22230954, PubMed:23911289). Acts by recruiting chromatin modifiers, such as histone deacetylases HDAC1, HDAC2 and HDAC3 (PubMed:22230954). Required to activate the histone deacetylase activity of HDAC3 (PubMed:22230954). Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival (PubMed:18212045, PubMed:23911289). Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024).
Isoform 1
Isoform 1 and isoform 4 have different affinities for different nuclear receptors.
Isoform 4
Isoform 1 and isoform 4 have different affinities for different nuclear receptors.
Sequence Similarities
Belongs to the N-CoR nuclear receptor corepressors family.
Tissue Specificity
Ubiquitous (PubMed:10077563). High levels of expression are detected in lung, spleen and brain (PubMed:10077563).
Cellular localization
- Nucleus
Alternative names
CTG26, NCOR2, Nuclear receptor corepressor 2, N-CoR2, CTG repeat protein 26, SMAP270, Silencing mediator of retinoic acid and thyroid hormone receptor, T3 receptor-associating factor, SMRT, TRAC