NCR1

Function

Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Post-translational modifications

N-glycosylated.

O-glycosylated.

Sequence similarities

Belongs to the natural cytotoxicity receptor (NCR) family.

Tissue specificity

Selectively expressed by both resting and activated NK cells.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein

Alternative names

• Natural cytotoxicity triggering receptor 1
• Lymphocyte antigen 94 homolog
• NK cell-activating receptor
• Natural killer cell p46-related protein
• NK-p46
• NKp46
• hNKp46
• NCR1
• LY94

Database links

• entrezGene:9437
• omim:604530
• swissprot:O76036

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Other research areas

• Immuno-oncology

Molecular weight

34481Da