NCR1

Function

Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Post-translational modifications

N-glycosylated.

O-glycosylated.

Sequence Similarities

Belongs to the natural cytotoxicity receptor (NCR) family.

Tissue Specificity

Selectively expressed by both resting and activated NK cells.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein

Alternative names

CD335, LY94, NCR1, Natural cytotoxicity triggering receptor 1, Lymphocyte antigen 94 homolog, NK cell-activating receptor, Natural killer cell p46-related protein, NK-p46, NKp46, hNKp46

Database links

swissprot:O76036 entrezGene:9437 omim:604530

Other research areas

• Immuno-oncology