NCS1
Function
Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity).
Sequence Similarities
Belongs to the recoverin family.
Cellular localization
- Golgi apparatus
- Postsynaptic density
- Cytoplasm
- Perinuclear region
- Cytoplasm
- Cell membrane
- Peripheral membrane protein
- Membrane
- Lipid-anchor
- Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions.
Alternative names
FLUP, FREQ, NCS1, Neuronal calcium sensor 1, NCS-1, Frequenin homolog, Frequenin-like protein, Frequenin-like ubiquitous protein