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NCSTN

Function

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.

Involvement in disease

Acne inversa, familial, 1

ACNINV1

A chronic relapsing inflammatory disease of the hair follicles characterized by recurrent draining sinuses, painful skin abscesses, and disfiguring scars. Manifestations typically appear after puberty.

None

The disease is caused by variants affecting the gene represented in this entry.

Post-translational modifications

N-glycosylated.

Sequence similarities

Belongs to the nicastrin family.

Tissue specificity

Detected in brain (at protein level) (PubMed:10993067). Widely expressed (PubMed:11396676).

Cellular localization

  • Membrane
  • Single-pass type I membrane protein
  • Cytoplasmic vesicle membrane
  • Single-pass type I membrane protein
  • Melanosome
  • Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Alternative names

  • KIAA0253
  • UNQ1874/PRO4317
  • UNQ1874/PRO4317
  • KIAA0253
  • NCSTN
  • Nicastrin

Target type

Proteins

Primary research area

Neuroscience

Molecular weight

78411Da

We found 9 products in 3 categories

Primary Antibodies

Target

Application

Reactive species

Proteins & Peptides

Target

Species of origin

Nature

Cell Lines & Lysates

Target

Cell type

Species or organism

Search our catalogue for 'NCSTN' (9)

Products

ab68145

Anti-Nicastrin antibody [EPR2575Y]

Recombinant
RabMAb
KO Validated
20ul selling size

ab247362

Anti-Nicastrin antibody [EPR2575Y] - BSA and Azide free

Recombinant
RabMAb
KO Validated