Ncstn
Function
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.
Post-translational modifications
N-glycosylated.
Sequence Similarities
Belongs to the nicastrin family.
Cellular localization
- Membrane
- Single-pass type I membrane protein
- Cytoplasmic vesicle membrane
- Single-pass type I membrane protein
- Melanosome
- Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Alternative names
Nicastrin, Ncstn